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Vitamin D + K2 comparison

Best Vitamin D + K2 Supplements Compared (2026): EDE Scored Reviews

Vitamin D deficiency is endemic in men 40+, with 40+ percent of US adults below 30 ng/mL serum 25(OH)D. The clinical effective dose for raising serum levels is 2000-5000 IU/day. K2 (MK-7 form) directs calcium into bones rather than arteries, making the D3+K2 stack the cardiovascular-bone synergy default.

We compared 4 products including standalone D3 NSF Sport variants and combined D3+K2 formulations. The TOP PICK delivers 5000 IU D3 + 100 mcg K2-MK7 at the lowest CPED in its quality tier.

Top Pick

Sports Research Vitamin D3 + K2 5000 IU + 100 mcg MK-7

Sports Research

Vitamin D3 + K2 5000 IU + 100 mcg MK-7

EDE Score

90/100

Verdict

Top pick

CPED

$0.43 / effective day/day

Sports Research Vitamin D3 + K2 delivers 5000 IU vegan lichen D3 plus 100 mcg MK-7 (the clinically-superior K2 form) in coconut MCT carrier. We score it 90/100 (TOP PICK). CPED $0.43/day. The vitamin D + K2 combo done right.

Best Value

Thorne

Vitamin D + K2 Liquid
Buy$0.20 / effective day/day

Approximately $84/year cheaper than the Top Pick at clinical full dose.

Read full review →

Full comparison

Sorted by EDE Score (highest first). Tap a product name to read the full review.

Frequently asked questions

Why pair vitamin D with K2?
K2 (especially the MK-7 form) activates osteocalcin and matrix Gla-protein, the proteins that direct calcium into bone matrix and away from arterial walls. Vitamin D raises calcium absorption from the gut; without K2, that calcium can deposit in arteries. The combination minimises this risk while maximising bone benefit.
How much vitamin D do men 40+ need?
Most clinical guidelines target serum 25(OH)D between 30-60 ng/mL (75-150 nmol/L). Reaching this typically requires 2000-5000 IU/day for non-deficient adults; deficient users (below 20 ng/mL) often need 6000-10000 IU/day for 8-12 weeks before maintenance. Test serum 25(OH)D, do not just guess.
Should I take vitamin D with food?
Yes. Vitamin D is fat-soluble; absorption can drop by 30-50 percent on an empty stomach. Take with the largest meal of the day for optimal uptake. Olive oil, avocado, eggs, and fish provide adequate dietary fat.
MK-4 or MK-7 form of K2?
MK-7 is preferred for once-daily dosing because of its 72-hour half-life versus MK-4's 1-2 hours. MK-4 requires multiple daily doses to maintain blood levels. Most premium D3+K2 products use MK-7 in the 90-180 mcg range.

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